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I-Nitroimidazole eshibhileCAS: 527-73-1

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I-Nitroimidazole eshibhileCAS: 527-73-1

Umaphakathi weMisonidazole, i-oncology radiosensitizer, isetshenziswa njengesihlanganisi semvelo esiphakathi.
Isetshenziselwa ukulungisa i-boric acid efakwe esikhundleni se-nitroimidazole njenge-precursor ye-hypoxic tissue imaging. Ibuye isetshenziselwe ukulungiselela ama-radiosensitizers akhethiwe atholakala esizeni ngamathumba acebile kuma-estrogen receptors.


Imininingwane yomkhiqizo

Amathegi womkhiqizo

Isingeniso Somkhiqizo

Igama lesiNgisi: 2-Nitroimidazole
I-CAS: 527-73-1
Ama-alias: 11a; amicin; AZOMYCIN; ro05-9129; AZOMYCINE; 2-NITROMIDAZOLE; 2-nitro-imidazo; 2-Nitroimidaxole; WLN: T5M CNJ BNW; 2-NITROIMIDAZOLE
Iphuzu lokuncibilika: 287 ° C (dec) (kukhanyisiwe)
Indawo yokubilisa: 211.75 ° C
Ubuningi: 1.5988
Inkomba yokubonisa: 1.4264
Izimo zokugcina: Ifriji
Ukuncibilika: I-NH4OH: i-soluble50mg / mL, i-yellowtoorange ecacile

Ukubukeka

I-PKA: 8.72 ± 0.10 (Okubikezelwe)
Umbala: Lightyellowtokhaki - luhlaza okotshani
Izakhiwo Zamakhemikhali: I-crystal ekhanyayo ephuzi. Iphuzu lokuncibilika 283 ℃ (ukubola). I-Soluble ku-methanol, i-ethanol, i-acetone, i-ethyl acetate, ayincibiliki ku-ether, chloroform

Sebenzisa:

Umaphakathi weMisonidazole, i-oncology radiosensitizer, isetshenziswa njengesihlanganisi semvelo esiphakathi.
Isetshenziselwa ukulungisa i-boric acid efakwe esikhundleni se-nitroimidazole njenge-precursor ye-hypoxic tissue imaging. Ibuye isetshenziselwe ukulungiselela ama-radiosensitizers akhethiwe atholakala esizeni ngamathumba acebile kuma-estrogen receptors.

Faka isicelo

I-Nitroimidazole (2-nitroimidazole) yinto eluhlaza eyisisekelo yokwenziwa kanye nokwenziwa kwamakhemikhali e-nitroimidazole kuma-radiosensitizers we-electronophilic. Izakhi ezifakwe esikhundleni se-N ezilungiselelwe kusuka ku-2-nitroimidazole zisetshenzisiwe njengama-anti-tumor radiosensitizers ezifundweni zokwelashwa. 2. I-Chemicalbook-based nitroimidazole ibaluleke kakhulu phakathi kwezinhlobonhlobo ze-radiotherapy sensitizers zamathumba, njengeMisonidazole, pimonidazole, etanidazole, njll.
Ingemuva: Isimila esibi yisifo esivamile esisongela kakhulu impilo yomuntu. Cishe amaphesenti angama-70 kuye kwangama-80 alezi zicubu adinga ukwelashwa ngemisebe. Ama-Radiosensitizers ahehe ukunakwa kakhulu kwi-radiotherapy ngenxa yekhono lawo lokukhulisa ukuzwela kwamangqamuzana wesimila emisebeni. I-2-nitroimidazole ingumgogodla obalulekile wezinhlobonhlobo ze-radiotherapy sensitizers zomdlavuza, njenge-Misonidazole, i-pimonidazole, i-etanidazole, njll. 2-nitroimidazole.

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